摘要 |
1. Technical Result Increase in efficiency of treating tumors. 2. Essence The use of compounds of the structure formula wherein R, R1, R2, R3, R4 and Z have the values indicated in the description as anti-tumor means, for treating tumors, in particular, in cases of drug resistance and metastatic carcinoma, and as angiogenesis inhibitors having distinctly fewer side effects, in particular, distinctly lower neurotoxicity and pharmaceutical composition containing said compound. 3. Field of Application Medicine. |