BROAD SPECTRUMA ANTAGONISTS AND VACCINES DIRECTED AGAINST PYROGENIC EXOTOXINS

摘要

The invention relates to peptides comprising an amino acid sequence homologous to the amino sequence of a fragment of a pyrogenic exotoxin, and functional derivatives of said peptides, capable of eliciting protective immunity against toxic shock induced by a pyrogenic exotoxin or by a mixture of pyrogenic exotoxins and of protecting against toxic shock induced by pyrogenic exotoxins. The invention also relates to broad spectrum pharmaceutical composition s and methods for the treatment, protection against or short term prophylaxis of toxin-mediated activation of T cells and toxic shock induced by a pyrogenic exotoxin or by a mixture of pyrogenic exotoxins, comprising at least one peptide of the invention or derivative thereof, and to broad spectrum vaccines for conferring long term immunity against toxic shock induced by at least one pyrogenic exotoxin are provided. The invention also relates to composition and method for the treatment of incapacitation induced by at least one pyrogenic exotoxin.