| 发明名称 |
NOVEL SUBSTITUTED SALICYLIC ACIDS |
| 摘要 |
A compound of the formula Het-NR-SO2-Ph2-A-Ph1 (COOH)(OH) and tautomic form, salts, solvates, C1-6 alkyl esters and pharmaceutical compositions of the compound. Ph1 and Ph2 are benzene rin gs with the proviso that carboxy and hy- droxy are ortho to one another. Het includes an optionally substituted heterocyclic ring which includes conjugated double bonds and binds to nitrogen in NR. The compound is characterized in that A i s a bridge which is stable against reduction because it is not azo, and in that R is hydrogen or lower alkyl. The inventi on also includes the preparation of the compound and its use as a drug, particularly for treating autoimmune diseases.</SDOAB >
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| 申请公布号 |
CA2123697(C) |
申请公布日期 |
2003.12.09 |
| 申请号 |
CA19922123697 |
申请日期 |
1992.11.04 |
| 申请人 |
KABI PHARMACIA AB |
发明人 |
AGBACK, KARL HUBERT;BERGLINDH, THOMAS;AHRGREN, LEIF;HARALDSSON, MARTIN;OLSSON, LARS-INGE;SMEDEGARD, GORAN |
| 分类号 |
A61K31/41;A61K31/415;A61K31/42;A61K31/421;A61K31/426;A61K31/428;A61K31/44;A61K31/4402;A61K31/4418;A61K31/495;A61K31/496;A61K31/4965;A61K31/50;A61K31/505;A61K31/603;A61P1/00;A61P29/00;A61P37/02;A61P37/06;C07D213/75;C07D213/76;C07D213/78;C07D233/88;C07D233/90;C07D237/20;C07D239/42;C07D239/69;C07D241/20;C07D249/12;C07D249/14;C07D261/14;C07D261/16;C07D263/28;C07D277/20;C07D277/22;C07D277/32;C07D277/38;C07D277/82;(IPC1-7):C07D213/76;C07D249/02;C07D275/03;C07D241/22;A61K31/395;C07D231/42;C07D263/50 |
主分类号 |
A61K31/41 |
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