摘要 |
The invention relates to novel sulfonamide compounds having 5-HT7 receptor antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS and other disorders.wherein:Q is phenyl or thienyl;R<1 >is halogen, hydroxy, C1-6alkyl, CF3, OCF3 or C1-6alkoxy;m is 0, 1, 2 or 3;R<2 >is C1-4alkyl;X is carbon or CH,<CUSTOM-CHARACTER FILE="US06660751-20031209-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00001"/> is a single bond when X is nitrogen or CH or<CUSTOM-CHARACTER FILE="US06660751-20031209-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00002"/> is a double bond when X is carbon,D is a single bond, C=O, O or CH2 subject to the proviso that when X is nitrogen then D is not oxygen;P is a 5 or 6 membered heteroaryl ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a benzofused heteroaryl ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur;R<3 >is C1-6alkyl optionally substituted by NR<4>R<5>, aryl, arylC1-6alkyl, C1 6alkoxy, C1-6alkylthio, cyano, hydroxy, nitro, halogen, CF3, C2F5, NR<4>R<5>, CONR<4>R<5>, NR<4>COR<5>, S(O)pNR<4>R<5>, CHO, OCF3, SCF3, CH2OR<6>, CO2R<6 >or COR<6 >where p is 0, 1 or 2 and R<4>, R<5 >and R<6 >are independently hydrogen, C1-6alkyl, aryl or arylC1-6alkyl;n is 0, 1, 2 or 3.
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