Nucleic acid molecules encoding a KOR3 kappa opioid receptor and the methods of producing the encoded receptor

摘要

The subject invention provides recombinant nucleic acid molecule which encodes a kappa3 opioid receptor, and the receptor encoded thereby. The subject invention further provides related anti-sense oligonucleotide molecules. The subject invention further provides a related host vector system, and method for using same. The subject invention further provides polyclonal and monoclonal antibodies capable of specifically binding to kappa3 opioid receptor, methods for obtaining same, and methods of using same to detect the presence of, and quantitatively determine the amount of, kappa3 opioid receptor in a sample, image and quantitatively determine the amount of cell membrane-bound kappa3 opioid receptor present in a subject, determine a subject's potential sensitivity to a kappa3 opioid receptor-specific agent, determine the affinity of an agent for kappa3 opioid receptor, and identify agonists and antagonists of kappa3 opioid receptor.