发明名称 |
EMPLOYMENT OF ROTAVIRUS PROTEINS, DERIVED PROTEINS AND PEPTIDES FOR THE MODULATION OF TISSUE PERMEABILITY |
摘要 |
The present invention refers to the use of rotavirus proteins VP4, VP8 and their derived fusion proteins and peptides, for enhancing the delivery of pharmaceutical agents through the paracellular pathway. These rotavius proteins and derived peptides may addtionally be employed to reduce unwanted cellular adhesion that can occur between cancerous cells, or between normal cells as a result of surgery, injury, chemotherapy, disease, inflammation or other pathological conditions. |
申请公布号 |
WO03098991(A2) |
申请公布日期 |
2003.12.04 |
申请号 |
WO2003IB00280 |
申请日期 |
2003.01.10 |
申请人 |
CENTRO DE INVESTIGACIONES Y ESTUDIOS AVANZADOS DELI.P.N.;GONZALEZ-MARISCAL, LORENZA;NAVA-DOMINGUEZ, PORFIRIO |
发明人 |
GONZALEZ-MARISCAL, LORENZA;NAVA-DOMINGUEZ, PORFIRIO |
分类号 |
A61K38/16;A61K47/42;A61P35/00;C07K14/14;C12N7/01 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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