发明名称 |
Compositions and methods for modeling bacillus subtilis metabolism |
摘要 |
The invention provides an in silico model for determining a Bacillus subtilis physiological function. The model includes a data structure relating a plurality of B. subtilis reactants to a plurality of B. subtilis reactions, a constraint set for the plurality of B. subtilis reactions, and commands for determining a distribution of flux through the reactions that is predictive of a B. subtilis physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. A regulated B. subtilis reaction can be represented in a model of the invention by including a variable constraint for the regulated reaction. The invention further provides methods for making an in silico B. subtilis model and methods for determining a B. subtilis physiological function using a model of the invention.
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申请公布号 |
US2003224363(A1) |
申请公布日期 |
2003.12.04 |
申请号 |
US20020102022 |
申请日期 |
2002.03.19 |
申请人 |
PARK SUNG M.;SCHILLING CHRISTOPHE H.;PALSSON BERNHARD O. |
发明人 |
PARK SUNG M.;SCHILLING CHRISTOPHE H.;PALSSON BERNHARD O. |
分类号 |
G06F19/00;(IPC1-7):C12Q1/68;G06G7/48;G06G7/58;G01N33/48;G01N33/50 |
主分类号 |
G06F19/00 |
代理机构 |
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主权项 |
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地址 |
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