PARALLEL STRANDED DUPLEXES OF DEOXYRIBONUCLEIC ACID AND METHODS OF USE

摘要

A triplex comprising a hairpin having at least one polypirimidine sequence linked to a complementary polypurine wherein the polypurine sequence is at least one 8-aminoprurine such as 8-aminoadenine, 8-aminoguanine and 8-aminohypoxanthine, and at least one polypyrimidine target sequence that that is complementary and antiparallel to the polypurine sequence. The polypurine sequence binds the polypyrimidine target sequence by forming a triplex helix. Methods for preparing the hairpins and for stabilizing thentriplex are provided. Methods for targeting single-stranded oligonucleotides and DNA is described using the hairpins and triplexes of this invention.