EXPORT AND MODIFICATION OF (POLY)PEPTIDES IN THE LANTIBIOTICWAY

摘要

The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post- translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine- containing peptides, wherein extracellularly thioether rings may be formed.< /SDOAB>