V1A ARGININE VASOPRESSIN RECEPTOR DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO

摘要

The present invention relates to compositions and methods relating to the characterization and function of V1a vasopressin receptor. Specifically, the present invention provides transgenic animals comprising disruptions in a V1a vasopressin receptor gene and methods of treating diseases conditions, such as schizophrenia, diabetes and inflammatory bowel disease. The present invention further relates to agents that modulate V1a vasopressin receptor and methods of screening for agents that modulate V1a vasopressin receptor for the treatment of diseases and conditions such as schizophrenia, diabetes and inflammatory bowel disease.