The invention provides a method of increasing cytotoxic T lymphocyte (CTL) activity in a subject comprising administering to the subject a CTL activity stimulating amount of a peptide selected from the peptides described. A method of increasing gamma interferon (IFN- gamma ) secretion in a subject comprising administering to the subject an IFN- gamma secretion increasing amount of a peptide selected from the peptides described. A method of increasing interleukin (IL-2) secretion in a subject comprising administering to the subject an IL-2 secretion increasing amount of a peptide selected from the peptides described. A method of treating a subject diagnosed as having a disease associated with reduced CTL activity, comprising administering to the subject a CTL activity stimulating amount of a peptide selected from the peptides described. A method of treating a subject diagnosed as having a disease associated with reduced IFN- gamma activity, comprising administering to the subject an IFN- gamma activity stimulating amount of a peptide selected from the peptides described. A method of treating a subject diagnosed as having a disease associated with reduced IL-2 activity, comprising administering to the subject an IL-2 activity stimulating amount of a peptide selected from the peptides described.
申请公布号
WO03050136(A3)
申请公布日期
2003.12.04
申请号
WO2002US39109
申请日期
2002.12.06
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTHTH;RUSCETTI, FRANCIS, W.;RUFF, MICHAEL, R.