发明名称 |
MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) PROMOTER POLYMORPHISM IN INFLAMMATORY DISEASE |
摘要 |
Describe herein is a novel CATT-tetranucleotide repeat polymorphism at position -817 of the human Mif gene that functionally affects the activity of the Macrophage Inhibitory Factor (MIF) promoter in gene reporter assays. Four genotypes are described which comprise 5, 6, 7, or 8-CATT repeat units. Of these, the 5-CATT allele has the lowest level of basal and stimulated MIF promoter activity in vitro. The presence of the low expressing, 5-CATT repeat allele correlated with low disease severity in a cohort of rheumatoid arthritis patients. Methods, compositions and apparatus for detecting this CATT-tetranucleotide repeat polymorphism at position -817 of the human Mif gene, and for using same for assessing predisposition to severe inflammatory disease, are also disclosed. |
申请公布号 |
WO03060468(A3) |
申请公布日期 |
2003.12.04 |
申请号 |
WO2002US41051 |
申请日期 |
2002.12.23 |
申请人 |
THE PICOWER INSTITUTE FOR MEDICAL RESEARCH |
发明人 |
BAUGH, JOHN, A.;BUCALA, RICHARD;CHITNIS, SMITA;DONNELLY, SEAMUS, C.;GREGERSEN, PETER, K.;MONTEIRO, JOANITA |
分类号 |
G01N33/53;A61K31/573;A61K38/00;A61K39/395;A61K45/00;A61P29/00;A61P43/00;C12N15/09;C12Q1/68;G01N33/566 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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