摘要 |
A class of 8-fluoroimidazo[1,2-a]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the alpha2 and/or alpha3 and/or alpha5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.
|
申请人 |
MERCK SHARP & DOHME LIMITED;BLACKABY, WESLEY, PETER;CASTRO PINEIRO, JOSE, LUIS;GOODACRE, SIMON, CHARLES;HALLETT, DAVID, JAMES;HUMPHRIES, ALEXANDER, CHARLES;JONES, PHILIP;MERCHANT, KEVIN, JOHN;READER, MICHAEL |
发明人 |
BLACKABY, WESLEY, PETER;CASTRO PINEIRO, JOSE, LUIS;GOODACRE, SIMON, CHARLES;HALLETT, DAVID, JAMES;HUMPHRIES, ALEXANDER, CHARLES;JONES, PHILIP;MERCHANT, KEVIN, JOHN;READER, MICHAEL |