发明名称 |
Stavudine Polymorphic Form 1 process |
摘要 |
A process for the formation of Stavudine Polymorphic Form I from a mixture comprising Polymorphic Form I and at least one of Polymorphic Forms II and III is disclosed using the technique of Solution-Enhanced Dispersion by Supercritical Fluids (SEDS). A solution of the mixture in isopropyl alcohol/water is introduced into a particle formation vessel with a supercritical fluid under controlled temperature and pressure whereby the supercritical fluid substantially simultaneously disperses and extracts the solvent from the solution forming discrete particles of Stavudine Polymorphic Form I. A preferred supercritical fluid is carbon dioxide.
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申请公布号 |
US2003225279(A1) |
申请公布日期 |
2003.12.04 |
申请号 |
US20020269358 |
申请日期 |
2002.10.11 |
申请人 |
BRISTOW SIMON CRAWFORD;COCKS PHILIP MICHAEL;HARLAND RONALD;GANDHI RAJESH B. |
发明人 |
BRISTOW SIMON CRAWFORD;COCKS PHILIP MICHAEL;HARLAND RONALD;GANDHI RAJESH B. |
分类号 |
A61P31/18;C07H1/06;C07H19/06;(IPC1-7):A61K31/513;C0745/04 |
主分类号 |
A61P31/18 |
代理机构 |
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