SYSTEM AND METHOD FOR SCREENING FOR PROTEASE INHIBITORS AND PROTEASES

摘要

The present invention provides simple and effective systems and methods for screening for protease inhibitors or proteases. In one aspect, it uses a reporter protein that comprises an apoptotic protein and a recognition sequence of a protease of interest within the apoptotic protein to evaluate the effects of candidate inhibitors on the activity of the protease of interest. In another aspect, it uses a reporter protein that comprises an apoptotic protein and a protease recognition sequence within the apoptotic protein to determine whether a candidate protease is capable of recognizing and cleaving within or near the protease recognition sequence.