| 摘要 |
The present invention is directed to slective LXR modulators, small molecule compounds corresponding to Formula (I) wherein: R1 and R2 are independently hydrogen or optionally substituted alkyl, alkenyl, aryl, acyi, or alkaryl; R 3 is optionally substituted alkyl or aryl; each R4 is independently hydrogen, alkyl, aryl,.heteroaryl, hydroxy, alkoxy, cyano, nitro, amino, alkenyl, alkynyl, amido, alkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkylcarbonyl, alkylthiocarbonyl, arylthlocarbonyl, alkyl optionally substituted with one or more substituent selected from lower alkyl, halogen, hydroxyl, haloalkyl, cyano, nitro, carboxyl, amino, alkoxy and aryl, or aryl optionally substituted with one or more substituent selected from hydrogen, halogen, haloalkyl, hydroxy, lower alkyl, alkoxy, methylene dioxy, ethylenedioxy, cyano, nitro, atkylthio, alkylsulfonyl, sulfonic acid, sulfonamide, carboxyl derivatives, amino, aryl and heteroaryl; and a is 0-4, and is further directed to a process of treating a condition in a mammal tha t is modulated by LXR using a therapeutically effective dose of a compound of Formula I.
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