发明名称 |
USE OF MONOCARBOXYLATE TRANSPORTER PROTEIN FOR THYROID HORMONE TRANSPORT |
摘要 |
The invention provides a use of a monocarboxylate transporter protein or a functional part, derivative and/or analogue thereof for altering transport of a thyroid hormone or a functional part, derivative and/or analogue thereof across a membrane. Said monocarboxylate transporter protein preferably comprises MCT-8. An isolated molecule capable of specifically binding at least part of an MCT protein, at least part of a ligand of an MCT protein, or a nucleic acid encoding said MCT and/or ligand, is also herewith provided. Regulation of the bioavailability of thyroid hormone in a tissue enables interfering with (metabolic) diseases. Hence, the invention also provides pharmaceutical compositions comprising a compound capable of binding said MCT protein, or capable of influencing the binding or transporting of a ligand of said MCT protein. Methods for diagnosis and/or treatment of a disease such as a disorder of thyroid metabolism, non-thyroidal illness, obesity or cardiovascular illness are also provided, as well as bioassays for identifying or detecting a candidate drug capable of binding to or influencing at least part of said MCT protein.
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申请公布号 |
WO03099864(A1) |
申请公布日期 |
2003.12.04 |
申请号 |
WO2003NL00384 |
申请日期 |
2003.05.23 |
申请人 |
STICHTING TOT BEVORDERING VAN DE WETENSCHAP DER ENDOCRINOLOGIE;FRIESEMA, EDITH, CATHARINA, HENDRIKA;VISSER, THEOFILUS, JOHANNES;KRENNING, ERIC, PAUL |
发明人 |
FRIESEMA, EDITH, CATHARINA, HENDRIKA;VISSER, THEOFILUS, JOHANNES;KRENNING, ERIC, PAUL |
分类号 |
A61K38/00;A61K38/17;A61K39/395;A61K45/00;A61K48/00;A61P5/14;C07K14/47;G01N33/50;(IPC1-7):C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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