CHIMERIC ALLOGRAFT TOLERANCE INDUCTION, MONITORING AND MAINTENANCE

摘要

A method is provided for inducing donor-specific tolerance and/or mixed dono r- recipient chimerism in an allograft transplant recipient, by administering t o a recipient of an allograft a therapeutically effective amount of an immunosuppressive agent that depletes T cells; administering to the recipien t of the allograft a therapeutically effective amount of anti-.alpha..beta. T cell receptor antibodies; implanting an allograft from an allograft donor in to the recipient; and implanting a therapeutically effective amount of bone marrow cells from the allograft donor into the allograft recipient.