发明名称 |
MN/CA IX-SPECIFIC MONOCLONAL ANTIBODIES GENERATED FROM MN/CA IX-DEFICIENT MICE AND METHODS OF USE |
摘要 |
Disclosed herein among other MN/CA IX-related inventions are new MN/CA IX-specific antibodies generated from MN/CA IX-deficient mice, preferably monoclonal antibodies and immunoreactive fragments and engineered variants thereof. Subsets of the new antibodies are to either the proteoglycan-like (PG) domain or to the carbonic anhydrase (CA) domain of MN/CA IX, and methods are provided by which antibodies can be prepared to the other MN/CA IX domains. Such new MN/CA IX-specific antibodies, fragments and variants are useful diagnostically/prognostically and therapeutically for cancer and precancer. Particularly preferred are the new monoclonal antibodies, fragments and variants that are specific for the non-immunodominant epitopes of MN/CA IX, which antibodies are, among other uses, useful to detect soluble MN/CA IX (s-CA IX) in body fluids, alone but preferably in combination with antibodies specific to the immunodominant epitopes of MN/CA IX, for example, in a sandwich assay. |
申请公布号 |
WO03100029(A2) |
申请公布日期 |
2003.12.04 |
申请号 |
WO2003US05136 |
申请日期 |
2003.02.21 |
申请人 |
BAYER CORPORATION;INSTITUTE OF VIROLOGY;PASTOREK, JAROMIR;PASTOREKOVA, SILVIA;ZATOVICOVA, MIRIAM;ZAVADA, JAN;ORTOVA GUT, MARTA |
发明人 |
PASTOREK, JAROMIR;PASTOREKOVA, SILVIA;ZATOVICOVA, MIRIAM;ZAVADA, JAN;ORTOVA GUT, MARTA |
分类号 |
C07K16/32;C07K16/40;C12N5/20 |
主分类号 |
C07K16/32 |
代理机构 |
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地址 |
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