PHENYLCYCLOHEXYLPROPANOLAMINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATION THEREOF

摘要

The invention relates to compounds of general formula (I), where R1 = H or a C1-C4 alkyl, -CO-C1-C4 alkyl, C1-C4 alkylphenyl or -CO-phenyl group, said phenyl being optionally substituted, R2 = H, a halogen atom, a -S(O)z-C1-C4 alkyl, where z is 0, 1 or 2, -NHSO2-C1-C4 alkyl, -NHSO2-phenyl or -NHSO2-C1-C4 alkylphenyl group, said phenyl being optionally substituted; R3 =a -X-R4 group, where X is a bond an oxygen atom or a -CH2- and R4 = H or a -CR5R6-COOR7 group, where R5, R6 and R7 independently = H or a C1-C4 alkyl, a phenyl group optionally substituted or fused with a dioxolane group, a -CO- NR8R9 - group, where R8 = H, a C1-C4 alkyl group or C1-C4 alkyl-C1-C4 alkoxy and R9 = a C1-C4 alkyl-C1-C4 alkoxy group, a -(CH2)n-A group, where n is 0, 1, 2, 3, or 4 and A = indolyl, fluorene or a substituted phenyl group, a -NH-phenyl group, optionally substituted or a -CH(R10)-(CH2)n-COOR11 group where n is 0, 1, 2 or 3 and R11 = H or a C1-C4 alkyl group and R10 = H, a C1-C4 alkyl, a -CH2-phenyl, said phenyl being optionally substituted, or a -COOR12 group where R12 = H or a C1-C4 alkyl group, the method for production and use in therapeutic applications thereof.