| 摘要 |
Antagonistic peptides of prostaglandin E2 receptor subtype EP4 and their use in the treatment or prevention of medical conditions associated with oligour ic nephropathy, bone resorption, abnormal intestinal crypt cell proliferation o r patency of the ductus arteriosus and the like are provided herein. The antagonistic peptides of the present invention possess general formula (I): wherein X is selected from the group consisting of a hydrogen atom, a sequen ce of 1 to 3 amino acids, and protecting groups such as a carbamate group and a n acyl group; and wherein Y is selected from the group consisting of a hydroge n atom, 1 to 5 L-lysine residues, phosphate, sulfate and 1 to 5 ethylene glyco l residues.
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