Hydroxy diphenyl ether compounds as anti-inflammatory agents

摘要

Disclosed is the use of hydroxydiphenylether compounds of formula <CHEM> , wherein R1, R2 and R3, independently from each other are hydrogen; hydroxy; C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; C1-C20alkoxy; C1-C6alkylcarbonyl; phenyl; or phenyl-C1-C3alkyl; R4 is hydrogen, C1-C20alkyl; hydroxy-substituted C1-C20alkyl; C5-C7cycloalkyl; hydroxy; formyl; acetonyl; allyl; carboxy; carboxy-C1-C3alkyl; carboxyallyl; C2-C20alkenyl; C1-C6-alkyl-carbonyl; C1-C3alkylcarbonyl-C1-C3alkyl; phenyl; or phenyl-C1-C3alkyl; and R5 is hydrogen; C1-C20alkoxy; or C1-C6alkylcarbonyl; as pharmaceutical active agents and to pharmaceutical compositions containing them.