| 摘要 |
PROBLEM TO BE SOLVED: To provide a resonance frequency analytical method for a DNA-metal particulate system capable of analyzing hybridization of DNA highly sensitively, highly efficiently and highly accurately. SOLUTION: A laser beam 2 is reflected by a mirror 3 and branched in two by a beam splitter 4. One laser beam 2A is reflected at an extremely slight angle by a mirror 3A, and the other laser beam 2B is transmitted through a phase modulator 5 and reflected by a mirror 3B, and both laser beams 2A, 2B are returned to the beam splitter 4. A sample cell 6 where the DNA-metal particulate system is arranged is irradiated with the coupled laser beam 2C, to thereby generate interference fringes in a sample. A radiation pressure of light is applied periodically to the metal particles by scanning the interference fringes, to thereby vibrate forcibly the metal particles, and the position of the metal particles is observed by an observation photodiode 8, to thereby analyze the resonance frequency of the DNA-metal particulate system. COPYRIGHT: (C)2004,JPO
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