发明名称 |
Means for use in treating diseases correlated with or caused by non-physiological levels of microtubule-associated pp2ac |
摘要 |
The present invention relates to a method of preventing or treating a disease correlated with or caused by non-physiologically increased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a protein selected from the group of MID1 or MID2 or a nucleic acid encoding said protein. The invention further relates to a method of preventing or treating a disease correlated with or caused by non-physiologically decreased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically effective amount of a peptidic fragment of MID1 or MID2 wherein said peptidic fragment comprises amino acids 108-165 (preferably 110-165) of MID1, amino acids 108-165 (preferably 110-165) of MID2 or with an effective amount of a fragment of PP2Ac wherein said fragment comprises the binding site to a4 or of a peptide fragment of a4 comprising amino acids 236-279 or with an effective amount of a nucleic acid molecule encoding said peptide fragment or with an effective amount of a molecule interfering with the interaction of MID1 with a4 or with an effective amount of a molecule interfering with the expression or activity of MID1 and/or a 4. |
申请公布号 |
AU2003240254(A8) |
申请公布日期 |
2003.12.02 |
申请号 |
AU20030240254 |
申请日期 |
2003.05.15 |
申请人 |
MAX-PLANCK GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
SUSANN SCHWEIGER;SEBASTIAN HAESLER;LARS KLIMASCHEWSKI;HANS-HILGER ROPERS;ALEXANDER TROCKENBACHER;VANESSA SUCKOW;JOHN FOERSTER;JENNIFER WINTER;RAINER SCHNEIDER;SYBILLE KRAUSS |
分类号 |
A61K38/17;A61P25/28;A61P35/00;C12Q1/42;(IPC1-7):A61K38/53;A61K31/710 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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