发明名称 |
Transgenic mouse model for cardiac hypertrophy and methods of use thereof |
摘要 |
Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the invention. Further provided are transgenic animals generated using the transgene constructs. Further provided are enzyme-based, cell-based, and whole-animal-based assays for detecting substances having therapeutic activity toward cardiac hypertrophy. Further provided are compositions comprising substances which modulate levels of active product of a hypertrophy-sensitive gene. Further provided are methods of treating cardiac hypertrophy.
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申请公布号 |
US6657104(B1) |
申请公布日期 |
2003.12.02 |
申请号 |
US19980173799 |
申请日期 |
1998.10.15 |
申请人 |
TEXAS SYSTEMS, UNIVERSITY OF THE BOARD OF THE REGENTS;UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER |
发明人 |
GRANT STEPHEN R.;OLSON ERIC N.;MOLKENTIN JEFFREY D. |
分类号 |
A01K67/027;A61K31/436;A61K31/453;A61K31/711;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61K49/00;A61P9/04;A61P43/00;C07K14/58;C12N5/08;C12N15/09;C12N15/85;C12Q1/02;G01N33/50;(IPC1-7):C12N15/85;C12N15/86;C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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