摘要 |
This invention describes novel pyrazole compounds of formula III:wherein Z<1>, Z<2>, and Z<3 >are as described in the specification; Q is -S-, -O-, -N(R<4>)-, or -CH(R<6>)-; R<1 >is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and R<2 >and R<2'> are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
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