发明名称 2-ARYLIMINO-2,3-DIHYDROTHIAZOLES, AND THEIR USE THEREOF AS SOMATOSTATIN RECEPTOR LIGANDS
摘要 The invention concerns novel 2-arylimino-2,3-dihydrothiazole derivatives of general formula (I), their preparation methods and their use as medicines, in particular for treating pathological conditions or diseases wherein one (or several) somatostatin receptors is/are involved. Said pathological conditions include in particular acromegaly, pituitary adenoma or endocrine gastroenteropanceatic tumors including the carcinoid syndrome, and gastrointestinal bleeding. In general formula (I), R1 represents in particular an alkyl, aralkyl, cyclohexyl radical optionally substituted by an amino radical or R1 represents a -C(R11)(R12)-CO-R10 radical wherein R11 represents H, R12 represents in particular H, carbocyclic or heterocyclic alkyl, cycloalkyl or aralkyl and R10 represents in particular an aminoalkylamino radical; R2 represents a carcyclic or heterocyclic aryl radical optionally substituted; R3 represents in particular COR5 or a carbocyclic or heterocyclic alkyl, adamantyl, aryl radical optionally substituted, carbocyclic or heterocyclic aralkyl optionally substituted on the aryl group; and R5 represents a radical fixed by a nitrogen atom to the group CO.
申请公布号 PL353831(A1) 申请公布日期 2003.12.01
申请号 PL20000353831 申请日期 2000.07.21
申请人 SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES SC R.A.S. 发明人 MOINET CHRISTOPHE;SACKUR CAROLE;THURIEAU CHRISTOPHE
分类号 C07D277/20;A61K31/426;A61K31/427;A61K31/437;A61K31/438;A61K31/4439;A61K31/4523;A61K31/454;A61K31/473;A61K31/496;A61K31/497;A61K31/506;A61K31/5377;A61K31/551;A61P1/04;A61P1/12;A61P1/16;A61P1/18;A61P3/04;A61P3/10;A61P5/02;A61P5/08;A61P9/02;A61P11/00;A61P15/00;A61P17/06;A61P19/00;A61P19/02;A61P25/06;A61P25/28;A61P27/02;A61P31/04;A61P35/00;A61P35/02;A61P43/00;C07B61/00;C07D277/30;C07D277/42;C07D277/56;C07D417/04;C07D417/12;C07D417/14;C07D471/04 主分类号 C07D277/20
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