DADD, death activator death domain protein

摘要

An isolated polynucleotide encoding a protein having DADD protein activity is selected from: (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 12; (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 12 from nucleotide 794 to nucleotide 3052; (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 12 from nucleotide 1295 to nucleotide 3052; (d) a polynucleotide comprising the nucleotide sequence of SEQ ID NO: 12 from nucleotide 2726 to nucleotide 2929; (e) a polynucleotide encoding a DADD protein comprising the ino acid sequence of SEQ ID NO: 13; (f) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13 from amino acid 167 to amino acid 753; (g) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13 from amino acid 645 to amino acid 712; and (h) a polynucleotide capable of hybridizing under stringent conditions to any one of the polynucleotides specified in (a)-(g). Described are compositions comprising a protein having DADD protein activity which comprises an amino acid sequence selected from: (a) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13; (b) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13 from amino acid 167 to amino acid 753; (c) a polynucleotide encoding a DADD protein comprising the amino acid sequence of SEQ ID NO: 13 from amino acid 645 to amino acid 712; and The composition can be used in the manufacture of a medicament for inhibiting a TNF-R DADD death domain promoter, preventing or ameliorating an inflammatory condition. Also described are methods for identifying inhibitors of binding of a DADD protein to a second protein having a death domain, and host cells, vector and antibodies of the polynucleotide and protein.