Dihydropyrones with selected heterocycles replacing the phenyls bearing polar substituents used as HIV protease inhibitors

摘要

Dihydropyrones with tethered heterocycles having improved pharmacological properties that potently inhibit the HIV aspartyl protease blocking HIV infectivity are disclosed. These dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. Methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds are also disclosed.