| 摘要 |
A piperazine derivative or pharmaceutically acceptable addition salts thereof has the formula (I) wherein: R1, R2, R3 and R4 are independently hydrogen, halogen, alkyl, alkoxy, alkylthio, hydroxy, amino, mono or di alkylamino, cyano, nitro, perfluoroalkyl or perfluoroalkoxy and R5, R6, R7, and R8 are independently hydrogen or alkyl; provided that neither R1 or R2 is t-butyl and at least one of R3 and R4 are halogen. The compounds are useful for treating schizophrenia, mania, dementia, depression, anxiety, obsessive-compulsive disorder, substance abuse, Parkinson-like motor disorder or a motion disorder related to the use of a neuroleptic agent.
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