发明名称 Quinoline and quinazoline compounds useful in therapy
摘要 The invention provides compounds of formula (I), wherein R<1 >represents C1-4 alkoxy optionally substituted by one or more fluorine atoms; R<2 >represents H or C1-6 alkoxy optionally substituted by one or more fluorine atoms; R<3 >represents one or more groups independently selected from H, halogen, C1-4 alkoxy and CF3; in addition, R<2 >and one R<3 >group may together represent -OCH2-, the methylene group being attached to the ortho-position of the pendant phenyl ring; R<4 >represents a 4-, 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring being optionally fused to a benzene ring or a 5- or 6-membered heterocyclic ring containing 1 or 2 heteroatoms selected from N, O and S, the ring system as a whole being optionally substituted; X represents CH or N; and L is absent or represents a cyclic group or an open chain group; and the pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful in the treatment of inter alia benign prostatic hyperplasia.
申请公布号 US2003220332(A1) 申请公布日期 2003.11.27
申请号 US20030455546 申请日期 2003.06.04
申请人 PFIZER INC. 发明人 COLLIS ALAN JOHN;FOX DAVID NATHAN ABRAHAM;NEWMAN JULIE
分类号 A61K31/47;A61K31/495;A61K31/496;A61K31/505;A61K31/517;A61K31/535;A61K31/5355;A61K31/55;A61P7/00;A61P9/06;A61P9/12;A61P13/02;A61P15/00;C07D215/42;C07D239/94;C07D239/95;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/12;C07D405/14;C07D471/04;C07D491/04;C07D491/048;C07D491/052;C07D497/04;C07D513/04;(IPC1-7):A61K31/541;A61K31/537;C07D417/02;C07D413/02;C0743/02 主分类号 A61K31/47
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