The invention discloses a novel combinatorial library comprising a plurality of bifunctional molecules having the formula CF - PF wherein CF is a moiety of a specific chemical or biological activity and PF is a second moiety imparting the molecule tunable physical properties. Structural modifications in the second moiety vary the physical properties of the bifunctional molecule without significantly modifying the chemical or biological activity, for obtaining optimized effect of the chemical or biological activity at the environment where the chemical or biological activity is to be expressed. Optionally the second moiety may further imparts the molecule a second specific chemical or biological activity.
申请公布号
WO03014292(A3)
申请公布日期
2003.11.27
申请号
WO2002IL00642
申请日期
2002.08.06
申请人
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.;WARSHAWSKY, RIVKA;GRESSEL, JONATHAN;ROGACHEV, ILANA;WANG, YING
发明人
GRESSEL, JONATHAN;ROGACHEV, ILANA;WANG, YING;WARSHAWSKY, ABRAHAM DI