发明名称 |
CONTINUOUS PROCESS FOR THE ENANTIOSELECTIVE CATALYTIC HYDROGENATION OF BETA-KETOESTERS |
摘要 |
The present invention relates to a continuous process for the enantioselective catalytic hydrogenation of beta-ketoesters comprising providing a catalytic hydrogenation zone and maintaining it under conditions of temperature and pressure effective for the catalytic hydrogenation of beta-ketoesters; continuously supplying to the catalytic hydrogenation zone a substrate comprising a beta-ketoester to be hydrogenated, a catalyst effective for enantioselective hydrogenation of the beta-ketoester and hydrogen; contacting the substrate, the catalyst and the hydrogen in the hydrogenation zone for a residence time effective for at least partial enantioselective catalytic hydrogenation of the beta-ketoester; (d) continuously withdrawing from the hydrogenation zone a reaction product mixture comprising enantioselectively hydrogenated beta-ketoester, unreacted beta-ketoester, catalyst and hydrogen; (e) supplying the reaction product mixture to a separation zone and separating at least some of the enantioselectively hydrogenated beta-ketoester from the reaction product mixture; (f) withdrawing the separated enantioselectively hydrogenated beta-ketoester as product; and (g) optionally supplying at least part of the remaining material from the separation zone to the hydrogenation zone.
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申请公布号 |
WO03097569(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
WO2003GB02192 |
申请日期 |
2003.05.21 |
申请人 |
PHOENIX CHEMICALS LIMITED;PROCTOR, LEE, DAVID;WARR, ANTONY, JOHN |
发明人 |
PROCTOR, LEE, DAVID;WARR, ANTONY, JOHN |
分类号 |
C07B53/00;C07B61/00;C07C67/31;C07C69/675;(IPC1-7):C07C67/31 |
主分类号 |
C07B53/00 |
代理机构 |
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