发明名称 |
T cell receptor transfer into a candidate effector cell or a precursor thereof |
摘要 |
The present invention provides means and methods for generating effector cells that may be used for, for instance, adoptive immunotherapy. One aspect includes a method for providing a candidate effector cell with an antigen-specific effector activity comprising providing the cell or a precursor thereof with a recombinant alphabeta T cell receptor specific for the antigen or an analogue of the receptor. In a preferred embodiment, the effector cell comprises cytotoxic activity.
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申请公布号 |
US2003219463(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
US20030391521 |
申请日期 |
2003.03.18 |
申请人 |
FALKENBURG JOHAN HERMAN F.;HEEMSKERK MARIA HUBERTA M. |
发明人 |
FALKENBURG JOHAN HERMAN F.;HEEMSKERK MARIA HUBERTA M. |
分类号 |
A61K35/12;A61K35/14;A61P31/00;A61P35/00;C12N5/0783;C12N5/10;(IPC1-7):A61K39/00;C12N5/08;C12N15/85 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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