摘要 |
The present invention provides methods of preparing 2-alkylcysteine derivatives, many of which can be performed stereoselectively. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. An example of these iron chelating agents are 4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-alkyl-thiazole-4-carboxylic acids, such as 4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-methyl-thiazole-4-carboxylic acid. |
申请人 |
GENZYME CORPORATION;CHANDA, BHANU, M.;CHERIAN, JOSEPH;CHORGHADE, MUKUND, S.;GIMI, RAYOMAND, H.;GURJAR, MUKUND, K.;MCDONNELL, PETER, D.;MHASKAR, SUNIL, V.;MOHAPATRA, DEDENDARA, K.;WOLSTENHOME-HOGG, PAUL |
发明人 |
CHANDA, BHANU, M.;CHERIAN, JOSEPH;CHORGHADE, MUKUND, S.;GIMI, RAYOMAND, H.;GURJAR, MUKUND, K.;MCDONNELL, PETER, D.;MHASKAR, SUNIL, V.;MOHAPATRA, DEDENDARA, K.;WOLSTENHOME-HOGG, PAUL |