发明名称 |
NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS |
摘要 |
Compounds represented by formula (I), wherein R<2> is selected from the group consisting of H, (C1-4)alkyl, halo, haloalkyl, OH, (C1-6)alkoxy, NH(C1-4alkyl) or N(C1-4alkyl)2; R<4> is H or Me; R<5> is H or Me; R<11> is H, (C1-4)alkyl, (C3-4)cycloalkyl and (C1-4)alkyl-(C3-4)cycloalkyl; A is a connecting chain of (C1-3)alkyl; B is O or S; n is 0 or 1; wherein when n is 0: Ring C is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted; and E is CONR<12>R<13> ; CONHNR<14>R<15>; NR<16>COR<17>; NR<18>SO2(C1-6)alkyl; SO2NR<19>R<20>; or SO2R<21>; or when n is 1: Ring C is as defined above and E is a single bond or a connecting group; and Ring D is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted with from 1 to 5 substituents; or a salt or a prodrug thereof are provided as inhibitors of HIV reverse transcriptase. |
申请公布号 |
WO03097644(A2) |
申请公布日期 |
2003.11.27 |
申请号 |
WO2003CA00718 |
申请日期 |
2003.05.14 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;SIMONEAU, BRUNO;LANDRY, SERGE;MALENFANT, ERIC;NAUD, JULIE;O'MEARA, JEFFREY;THAVONEKHAM, BOUNKHAM;YOAKIM, CHRISTIANE |
发明人 |
SIMONEAU, BRUNO;LANDRY, SERGE;MALENFANT, ERIC;NAUD, JULIE;O'MEARA, JEFFREY;THAVONEKHAM, BOUNKHAM;YOAKIM, CHRISTIANE |
分类号 |
A61K31/551;A61P31/18;A61P43/00;C07D471/14 |
主分类号 |
A61K31/551 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|