| 摘要 |
A method for controlling an embeded protein (including peptide) by photic stimulation, characterized in that it comprises a step of modifying nano particles comprising a hydrophilic polymer with a light-respondent compound (a compound undergoing the change of its structure by photic stimulation), to convert it to a hydrophobic material, and incorporating an objective protein (including peptide) to the inside of the resulting nano particles comprising a hydrophobic polymer. The method is based on the finding that, with respect to the utilization of a photic stimulation as a means for controlling the reversible change between hydrophilic and hydrophobic substances, the use of the dynamic association control of an associative molecule responding to the photic stimulation allows the achievement of a function similar to the molecular chaperone function to a protein. The method provides a means improved in the simplicity and easiness for use in controlling reversibly a physiological function of a protein (including peptide) or the like by the use of nano particles.
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