CAMPTOTHECIN DERIVATIVES AND POLYMERIC CONJUGATES THEREOF

摘要

Polymeric conjugates of camptothecin derivatives having increased circulating half-lives are disclosed. In preferred aspects, the E ring lactone of the camptothecin derivatives is opened and funtionalzed to allow attachment of a polymer such as PEG in the 17-or 20-position thereof. A representative example of such compound is (I) methods of preparing and using the same are also disclosed.