发明名称 |
Anticancer agents based on prevention of protein prenylation |
摘要 |
Prenylating enzymes are involved in modifying oncoproteins, such as RAS, so that growth of neoplastic cells becomes uncontrolled. Inactivation of such enzymes can prevent uncontrolled growth. alpha-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and/or specificity for a particular protein substrate. |
申请公布号 |
US2003219847(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
US20030437050 |
申请日期 |
2003.05.14 |
申请人 |
THE ARIZONA DISEASE CONTROL RESEARCH COMMISSION |
发明人 |
ROSE SETH D.;OTTERSBERG STEVEN R.;OKOLOTOWICZ KARL J.;ROBINSON DALE E.;HARTMAN ROSEMARIE;LEFLER SCOTT |
分类号 |
A61K31/12;A61K31/121;C12N9/10;C12Q1/48;(IPC1-7):C12Q1/48 |
主分类号 |
A61K31/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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