发明名称 |
CRYSTAL OF GLUCOKINASE PROTEIN, AND METHOD FOR DRUG DESIGN USING THE CRYSTAL |
摘要 |
Glucokinase is crystallized, the three-dimensional structure thereof is analyzed, and then a compound to be bonded to glucokinase is designed on the basis of the coordinate for the resulting three-dimensional structure. Specifically, glucokinase is freed of a part of amino acid residues being on the N-terminal side thereof, to thereby crystallize it, and the three-dimensional structure of the resulting crystal is elucidated through the X-ray crystallographic analysis thereof.
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申请公布号 |
WO03097824(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
WO2003JP06054 |
申请日期 |
2003.05.15 |
申请人 |
BANYU PHARMACEUTICAL CO., LTD.;KAMATA, KENJI;NAGATA, YASUFUMI;IWAMA, TOSHIHARU |
发明人 |
KAMATA, KENJI;NAGATA, YASUFUMI;IWAMA, TOSHIHARU |
分类号 |
C12N9/12;(IPC1-7):C12N9/12;C12Q1/48 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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