MUTEINS OF PLACENTAL GROWTH FACTOR TYPE 1, PREPARATION METHOD AND APPLICATION THEREOF
摘要
The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses, and pharmaceutical and cosmetic compositions containing said derivatives. The invention likewise relates to the production of antibodies for said derivatives and their use in the diagnosis and treatment of tumoral and non-tumoral pathologies.
申请公布号
WO03097688(A2)
申请公布日期
2003.11.27
申请号
WO2003IT00296
申请日期
2003.05.19
申请人
GEYMONAT S.P.A.;MAGLIONE, DOMENICO;BATTISTI, MAURO;CONTI, ETTORE;SALVIA, GIUSEPPE;TUCCI, MARINA;MION, ALBERTO
发明人
MAGLIONE, DOMENICO;BATTISTI, MAURO;CONTI, ETTORE;SALVIA, GIUSEPPE;TUCCI, MARINA;MION, ALBERTO