发明名称 |
VITAMIN-MITOMYCIN CONJUGATES |
摘要 |
The invention relates to vitamin-mitomycin conjugates, to a method of using the conjugates to selectively eliminate a population of pathogenic cells in a host animal harboring the pathogenic cells, and to a method of preparation of the conjugates. The conjugate is of general formula B-L-X wherein the group B is a vitamin, or an analog or a derivative thereof, that binds to a surface accessible vitamin receptor that is uniquely expressed, overexpressed, or preferentially expressed by a population of pathogenic cells, wherein the group L comprises a cleavable linker, and wherein the group X comprises a mitomycin compound, or an analog or a derivative thereof. An additional therapeutic agent, such as a chemotherapeutic agent, can be administered in combination with the conjugate.
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申请公布号 |
WO03097647(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
WO2003US14969 |
申请日期 |
2003.05.13 |
申请人 |
ENDOCYTE, INC.;VLAHOV, IONTCHO, RADOSLAVOV;LEAMON, CHRISTOPHER, PAUL |
发明人 |
VLAHOV, IONTCHO, RADOSLAVOV;LEAMON, CHRISTOPHER, PAUL |
分类号 |
A61K47/48;A61K31/407;A61K45/00;A61P35/00;A61P43/00;C07D475/02;C07D475/04;C07D498/02;C07D519/00;C07H23/00;(IPC1-7):C07D487/14;A61K31/40 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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