COMPOUNDS WHICH CAN BLOCK THE RESPONSE TO CHEMICAL SUBSTANCES OR THERMAL STIMULI OR MEDIATORS OF INFLAMMATION OF NOCICEPTORS, PRODUCTIONMETHOD THEREOF AND COMPOSITIONS CONTAININGSAME

摘要

The invention relates to compounds having formula (I), which can block the response to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, a production method thereof and compositions containing same. According to the invention, Ar is a phenyl group substitute d with one or more halogen groups; R1 is amino, hydroxyl or thiol, all of whic h may or may not be substituted with formula (II) or with aliphatic or cyclic groups; R2 is H or an alkyl, aryl, aralkyl or acyl group or formula (III); R 3 is H or formula (IV); R4 and R6 are H or an aliphatic or cyclic group; R5 is H or formula (V); R7 is H or an aliphatic or cyclic group; Z is amino, hydroxy l or thiol, all of which may or may not be substituted with aliphatic or cycli c groups; W is a linkage or formula (VI); X is a linkage or formula (VII); Y i s amino which may or may not be substituted with formula (VIII) or an alkyl, aryl, aralkyl or acyl group; m, q and s can vary between 1 and 9 and n and p can vary between 1 and 10.