发明名称 |
High throughput method for screening candidate compounds for biological activity |
摘要 |
A method for screening candidate compounds for an ability to modulate the biological activity of a target. The method includes the steps of providing a substrate comprising a target and an indicator, the substrate adapted for receiving a plurality of candidate compounds; contacting the substrate with a plurality of candidate compound samples in a manner wherein an identity of each candidate compound can be determined and wherein the candidate compounds in the candidate compound samples interact with the target in the substrate; detecting a signal, the signal produced by the indicator upon interaction between the target and a candidate compound; and identifying a candidate compound as a modulator of the biological activity of the target based upon an amount of signal produced.
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申请公布号 |
US2003219825(A1) |
申请公布日期 |
2003.11.27 |
申请号 |
US20020297976 |
申请日期 |
2002.12.12 |
申请人 |
HAIZLIP JILL ELAINE;IGNAR DIANE MICHELE;JAYAWICKREME CHANNA K;KING HOLLY KAY;LIACOS JAMES ARTHUR;MILLS KIRSTEN;RUAN JASON J;SAULS JR HOWARD RAY;SHAFFER JOEL EDWARD |
发明人 |
HAIZLIP JILL ELAINE;IGNAR DIANE MICHELE;JAYAWICKREME CHANNA K;KING HOLLY KAY;LIACOS JAMES ARTHUR;MILLS KIRSTEN;RUAN JASON J;SAULS JR HOWARD RAY;SHAFFER JOEL EDWARD |
分类号 |
C12Q1/02;C40B30/04;G01N33/15;G01N33/50;G01N33/566;G01N33/68;(IPC1-7):G01N33/53;G01N33/567;G01N33/543 |
主分类号 |
C12Q1/02 |
代理机构 |
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