| 摘要 |
Drug delivery devices for administering an active agent or a combination of active agents to a subject are provided. Specifically, multi-layer mucoadhesive drug delivery device are provided, including: (a) a mucoadhesive layer, containing at least one non-ionic polymer, at least one anionic polymer, at least one swelling modifier, and at least one buffering agent; (b) an effervescent layer, containing at least one permeation enhancer, an effervescent couple, comprising an anhydrous acid and an alkalizing agent, and at least one binder; and, (c) at least one active agent; wherein the at least one active agent is contained in both the mucoadhesive layer and the effervescent layer; wherein the at least one active agent contained in the effervescent layer is released from the drug delivery device along with the at least one permeation enhancer within 10 minutes, more preferably within 5 minutes, most preferably within 1 minute, of administration of the drug delivery device to a subject and wherein the at least one active agent contained in the mucoadhesive layer is released from the drug delivery device over a period of at least 8 hours, more preferably at least 12 hours, most preferably at least 24 hours, preferably with near zero-order kinetics, more preferably with zero-order kinetics. Methods of administering active agents to a subject using such multi-layer mucoadhesive drug deliver devices are also provided.
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