发明名称 |
COPOLYMERS FOR SUPPRESSION OF AUTOIMMUNE DISEASES, AND METHODS OF USE |
摘要 |
<p>Random three- and four-amino acid copolymers having lengths of 14-,35- and 50-amino acid residues are provided. Fifty-mers of FEAK were effective inhibitors of MBP 85-99 or proteolipid protein (PLP) 40-60-specific HLA-DR-2-restricted T cell clones. These copolymers efficiently suppressed EAE induced in susceptible SJL/J (H-2<S>) strain of mice with either whole spinal cord homogenate (WSCH) or with the encephalitogenic epitope PLP 139-151. YFAK 50-mer having a molar ratio of about y 0.8:F 0.2 inhibited binding of biotinylated MBP 85-99 epitope to HLA-DR-2 molecules more efficiently than either unlabeled MBP 85-99 or Copaxone3. YFAK and FAK copolymers efficiently suppressed EAE induced in SJL/J (H-2<S>) mice with the encephalitogenic epitope PLP 139-151. Copolymers YFK, VYAK and tryptophan-containing VWAK were efficacious in alleviating severity and duration of symptoms of EAE induced by MBP 85-99, in a humanized mouse model expressing genes for both an HLA-DR-2 linked to multiple sclerosis (MS) in humans and for a T cell receptor from an MS patient.</p> |
申请公布号 |
WO03029276(A3) |
申请公布日期 |
2003.11.27 |
申请号 |
WO2002US31399 |
申请日期 |
2002.10.03 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;STROMINGER, JACK, L.;FRIDKIS-HARELI, MASHA |
发明人 |
STROMINGER, JACK, L.;FRIDKIS-HARELI, MASHA |
分类号 |
A61K45/00;A61K38/00;A61K38/20;A61K38/21;A61K38/55;A61P3/10;A61P5/14;A61P7/04;A61P17/06;A61P21/04;A61P25/00;A61P29/00;A61P31/04;A61P37/02;A61P43/00;C07K14/00;(IPC1-7):A61K38/00;A61K39/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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