PROPANOLAMINE DERIVATIVES, PROCESS FOR PREPARATION OF 3-N-METHYLAMINO-1-(2-THIENYL)-1-PROPANOLS AND PROCESS FOR PREPARATION OF PROPANOLAMINE DERIVATIVES

摘要

A process is provided by which 3-N-methylamino-1-(2- thienyl)-1-propanols represented by the general formula (I) can be easily prepared in the form of a racemate or an optically active substance (of S- or R-configuration) at a low cost and in a high yield: (I) wherein R<1> is hydrogen, C1-8 acyl, substituted or unsubstituted C1-8 alkyloxycarbonyl, or substituted or unsubstituted phenyloxycarbonyl; and R<2> is hydrogen, C1-8 alkyl, substituted or unsubstituted benzyl, C1-8 acyl, substituted or unsubstituted C1-8 alkyloxycarbonyl, or substituted or unsubstituted phenyloxycarbonyl, with the proviso that a case wherein R<1> is hydrogen and R<2> is methyl or hydrogen is excepted.