PROCESS FOR PRODUCING (3R,5S)-(E)-7- 2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-QUINOLIN-3-YL -3,5-DIHYDROXYHEPT-6-ENIC ACID ESTERS

摘要

A process for producing a compound represented by the following formula (IV): <CHEM> (wherein R denotes a hydrogen atom, an alkyl group, or an aryl group), comprising reducing a compound selected from the group consisting of: a compound represented by the following formula (I): <CHEM> (wherein R is as defined in the formula); a compound represented by the following formula (II): <CHEM> (wherein R is as defined in the formula); and a compound represented by the following formula (III): <CHEM> (wherein R is as defined in the formula), by reacting the compound with a cell of a microorganism and/or a cell preparation thereof capable of stereo-selectively reducing a keto group.