发明名称 |
Crystallizable compositions comprising a hepatitis c virus ns3 protease domain/ns4a complex and crystals thereby obtained |
摘要 |
The invention relates to methods of using the structure coordinates of hepatits C virus protease in complex with a synthetic NS4A to evaluate the potential of a chemical entity to associate with a molecule or molecular complex comprising a binding pocket of tNS3 or to identify a potential agonist or antagonist of a molecule comprising a NS3-like binding pocket. |
申请公布号 |
EP1364961(A1) |
申请公布日期 |
2003.11.26 |
申请号 |
EP20030015398 |
申请日期 |
1997.09.12 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
KIM, JOSEPH L.;MORGENSTERN, KURT A.;LIN, CHAO;FOX, TED;THOMSON, JOHN A. |
分类号 |
C07K14/18;(IPC1-7):C07K14/18;C07K1/00;C30B7/00;G06F17/50 |
主分类号 |
C07K14/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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