发明名称 |
SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE |
摘要 |
This invention provides novel compounds of formula (I) wherein Y is -CH2- or - CO-; R1 is F, C1 or OH; R2 is H, F or C1; and R3 is H, CH3 or CH2CH3, excluding 4-(5-chloro-2,3-dihydro-1H-inden-2 - yl)-1H-imidazole and 4-(4-chloro-2,3-di- hydro-1H-inden-2-yl)-1H-imidazole and their non-toxic acid addition salts an d mixtures thereof. Processes for the prepara- tion of these compounds are described, as are novel pharmaceutical compositions comprising at least one of the compounds or their salts. The compounds and their non-toxic salts exhibit valuable pharmacological activity and are highly selective and long acting antagonists at a2-adrenoceptors. Their peroral bioavailabili ty is good. The compounds are especially useful in the treatment of cognitive disorders.
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申请公布号 |
CA2117305(C) |
申请公布日期 |
2003.11.25 |
申请号 |
CA19922117305 |
申请日期 |
1992.12.18 |
申请人 |
ORION-YHTYMA OY |
发明人 |
KARJALAINEN, ARTO JOHANNES;VIRTANEN, RAIMO EINARI;KARJALAINEN, ARJA LEENA;ELORANTA, MAIRE MARJATTA;SALONEN, JARMO SAKARI;SIPILA, HANNU TAPANI;HAAPALINNA, ANTTI SAKARI |
分类号 |
C07D233/64;A61K31/415;A61K31/4164;A61K31/496;A61P1/18;A61P3/04;A61P9/12;A61P25/02;A61P25/28;C07D;C07D233/54;(IPC1-7):C07D233/64 |
主分类号 |
C07D233/64 |
代理机构 |
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